Synthesis, Characterization and Antifungal Activity Studies on Quinazoline-4-one Derivatives Containing 8-Hydroxy Quinazoline Ligand and its Metal Chelates

Abstract

The novel ligand HL₄ was synthesized from anthranilic acid. For this quinazoline-4-one 8- hydroxyquinoline (QHQ) condensed molecules were used. The transition metal chelates like Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) with HL₄ have been prepared and characterized by physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, IR, NMR and electronic spectral data. The stoichiometry of the complex has been found to be 1:2 (metal:ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry around Cu(II) and tetrahedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was screened against various fungi.