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TLC and HPLC Enantioseparation of Amino Containing Pharmaceutical Using Levofloxacin as Chiral Derivatizing Reagent in Indirect Method
Corresponding Author(s) : Manohar Lal
Asian Journal of Chemistry,
Vol. 29 No. 9 (2017): Vol 29 Issue 9
Abstract
Indirect reversed-phase high-performance liquid chromatographic (RP-HPLC) and normal phase thin layer chromatographic method was developed for the separation of enantiomers of (RS)-atenolol using levofloxacin as chiral derivatizing reagent. The indirect separations of the derivatized analytes were performed on C18 column in HPLC and on normal phase plane TLC plates. The effects of organic modifier, mobile phase composition, pH and temperature on the separation were investigated.
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- A.G. Gilman, L.S. Goodman and A. Gilman, Goodman and Gilman's The Pharmacological Basis of Therapeutics, Macmillan, New York (1980).
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- R. Bhushan and S. Tanwar, Biomed. Chromatogr., 23, 787 (2009); https://doi.org/10.1002/bmc.1187.
- R. Bhushan and S. Tanwar, J. Chromatogr. A, 1217, 1395 (2010); https://doi.org/10.1016/j.chroma.2009.12.071.
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- S.C. Sweetman, Martindale, The Complete Drug Reference, Pharmaceutical Press, edn 33 (2002).
- G. Tamilarasi, T. Vetrichelvan, D. Vekappayya, R. Tharabai and K. Yuvarajan, J. Pharm. Pharm. Sci., 6, 646 (2014).
- V. Kannappan and S.S. Mannemala, J. Pharm. Biomed. Anal., 120, 221 (2016); https://doi.org/10.1016/j.jpba.2015.12.048.
- I.T. Lund, P.L. Bøckmann and E.E. Jacobsen, Tetrahedron, 72, 7288 (2016); https://doi.org/10.1016/j.tet.2016.02.018.
- T. Alizadeh, Sep. Purif. Technol., 118, 879 (2013); https://doi.org/10.1016/j.seppur.2013.08.032.
- G. Venkatesh, S. Ramanathan, S.M. Mansor, N.K. Nair, M.A. Sattar, S.L. Croft and V. Navaratnam, J. Pharm. Biomed. Anal., 43, 1546 (2007); https://doi.org/10.1016/j.jpba.2006.11.013.
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- R. Bhushan and S. Tanwar, Chromatographia, 68, 849 (2008); https://doi.org/10.1365/s10337-008-0758-4
References
A.G. Gilman, L.S. Goodman and A. Gilman, Goodman and Gilman's The Pharmacological Basis of Therapeutics, Macmillan, New York (1980).
T. Walle, J.G. Webb, E.E. Bagwell, U.K. Walle, H.B. Daniell and T.E. Gaffney, Biochem. Pharmacol., 37, 115 (1988); https://doi.org/10.1016/0006-2952(88)90763-0.
W.T. Comer and A.W. Gomoll, ed.: A. Burger, Medicinal Chemistry, Part II, Wiley-Interscience, New York, Cahp. 39, p. 1019 (1970).
R. Bhushan and S. Tanwar, Biomed. Chromatogr., 23, 1291 (2009); https://doi.org/10.1002/bmc.1252.
R. Bhushan and S. Tanwar, Biomed. Chromatogr., 23, 787 (2009); https://doi.org/10.1002/bmc.1187.
R. Bhushan and S. Tanwar, J. Chromatogr. A, 1217, 1395 (2010); https://doi.org/10.1016/j.chroma.2009.12.071.
M.J. Wilson, K.D. Ballard and T. Walle, J. Chromatogr. A, 431, 222 (1988); https://doi.org/10.1016/S0378-4347(00)83089-3.
I. Ilisz, A. Aranyi and A. Péter, J. Chromatogr. A, 1296, 119 (2013); https://doi.org/10.1016/j.chroma.2013.03.034.
S.C. Sweetman, Martindale, The Complete Drug Reference, Pharmaceutical Press, edn 33 (2002).
G. Tamilarasi, T. Vetrichelvan, D. Vekappayya, R. Tharabai and K. Yuvarajan, J. Pharm. Pharm. Sci., 6, 646 (2014).
V. Kannappan and S.S. Mannemala, J. Pharm. Biomed. Anal., 120, 221 (2016); https://doi.org/10.1016/j.jpba.2015.12.048.
I.T. Lund, P.L. Bøckmann and E.E. Jacobsen, Tetrahedron, 72, 7288 (2016); https://doi.org/10.1016/j.tet.2016.02.018.
T. Alizadeh, Sep. Purif. Technol., 118, 879 (2013); https://doi.org/10.1016/j.seppur.2013.08.032.
G. Venkatesh, S. Ramanathan, S.M. Mansor, N.K. Nair, M.A. Sattar, S.L. Croft and V. Navaratnam, J. Pharm. Biomed. Anal., 43, 1546 (2007); https://doi.org/10.1016/j.jpba.2006.11.013.
R. Bhushan and S. Tanwar, Chromatographia, 70, 1001 (2009); https://doi.org/10.1365/s10337-009-1216-7.
R. Bhushan and S. Tanwar, Chromatographia, 68, 849 (2008); https://doi.org/10.1365/s10337-008-0758-4