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Vol. 29 No. 9 (2017): Vol 29 Issue 9

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Synthesis of Salicylic Acid Based Mixed Ligand Complexes: Their Protein Binding Affinities and Antimicrobial Activities

https://doi.org/10.14233/ajchem.2017.20829
Nidhi Aggarwal
Department of Chemistry, Lovely Professional University, Phagwara-144 411, India
Sameena Mehtab
Department of Chemistry, G.B. Pant University of Agriculture and Technology Pantnagar-263 145, India
Suman Maji
Department of Chemistry, Lovely Professional University, Phagwara-144 411, India

Corresponding Author(s) : Suman Maji

suman.18432@lpu.co.in

Asian Journal of Chemistry, Vol. 29 No. 9 (2017): Vol 29 Issue 9

Abstract

Present study is based upon synthesis, characterization, bovine serum albumin binding interactions and antimicrobial studies of mixed ligand complexes of zinc with salicylic acid or 3,5-dinitrosalicylic acid as primary ligand and 1,10-phenanthroline or 2,2-bipyridyl as secondary ligand. These complexes are characterized by UV-visible, IR and elemental analysis to determine the mode of binding between metal and ligand. The interaction of these complexes with protein molecules were studied by determining the binding constants from interaction with bovine serum albumin using UV-visible titration techniques. The antimicrobial activities of these complexes have been tested against bacteria and fungi. It has been observed that the above mentioned complexes show considerable antimicrobial activity compared to the free ligands.

Keywords

Mixed ligand complexes Salicylic acid 3,5-Dinitrosalicylic acid Bovine serum albumin Antimicrobial activity
Aggarwal, N., Mehtab, S., & Maji, S. (2017). Synthesis of Salicylic Acid Based Mixed Ligand Complexes: Their Protein Binding Affinities and Antimicrobial Activities. Asian Journal of Chemistry, 29(9), 2069–2073. https://doi.org/10.14233/ajchem.2017.20829
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