Synthesis of Some Novel Methyl- and Ethyl- 2-aminothiophene-3-carboxylate and Related Schiff-Bases

Abstract

Methyl- and ethyl-2-amino thiophene-3-carboxylate derivatives 1(a-h) were synthesized by a simple one-pot condensation reaction of the ketone, elemental sulphur and methyl- or ethylcyanoacetate in the presence of morpholine as a catalyst. Further reaction of these compounds with salicylaldehyde gave related Schiff-bases, 2(a-e). Yields of products following recrystallization from ethanol were in the range of 70-85 %. ¹H NMR and IR spectra and elemental analysis data were used to identification of these compounds.