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Vol. 22 No. 9 (2010): Vol 22 Issue 9

Electrochemical Study on the Interaction Between the Macrocyclic Copper(II) and Nickel(II) Complexes and Calf thymus DNA

Jian-Hong Bi
Deparment of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, P.R. China
Meng Li
School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, P.R. China.
Fu-Hou Yao
Zhejiang Jiuzhou Pharmaceutical Co., Ltd. Taizhou City, Zhejiang 318000, P.R. China
Yan Chen
Anhui Institute of Geological Experiments, Hefei 230001, P.R. China

Corresponding Author(s) : Jian-Hong Bi

bi010101@126.com

Asian Journal of Chemistry, Vol. 22 No. 9 (2010): Vol 22 Issue 9

Abstract

The interaction of the two tetraazamacrocyclic transition-metal complexes, ML(ClO4)2 (M = Cu2+, Ni2+, L = 5,12-dimethyl-7,14-diphenyl-1,4,8,11-tetraazamacrocyclic-4,11-diene) with calf thymus-DNA (CT-DNA) were studied by cyclic voltammetry. In the presence of CT-DNA, the oxidion peaks of [CuL]2+ and [NiL]2+ shifted to more positive values and the peak current increased significantly. The experimental results indicate that the two complexes could interact with CT-DNA mainly by intercalation binding mode.

Keywords

Azamacrocyclic transition-metal complex DNA Cyclic voltammetry Intercalation
(1)
Bi, J.-H.; Li, M.; Yao, F.-H.; Chen, Y. Electrochemical Study on the Interaction Between the Macrocyclic Copper(II) and Nickel(II) Complexes and Calf Thymus DNA. ajc 2010, 22, 7343-7346.
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