Syntheses of Biologically Active 1-(Substituted aminomethyl)- 3-(2'-naphthoxyacetylhydrazono)indolin-2-ones

Abstract

2-Naphthoxyacetic acid hydrazide (1) was condensed with indole-2,3-dione in ethanol to yield 3-(2'-naphthoxyacetylhydrazono)indolin-2-one (2) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-3-(2'-naphthoxyacetyl hydrazono)indolin-2-ones. The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have shown promising biological activity.