Synthesis and Biological Activities of New Series of Imidazolidin-2,4-dione Derivatives

Abstract

3-{[2-Furylmethylene]amino}imidazolidine-2,4-dione (2) was synthesized by compound 1, ethylchloroacetate and fused sodium acetate involved in cyclization method. A series of imidazolidin-2,4-dione derivatives (3a-3f) were synthesized by composition of compound 2 with 4-substituted benzaldehyde and hydrazine hydrate from Mannich base method. The chemical structures of the compounds were conformed by IR, ¹H NMR and elemental analysis. The synthesized compounds have been tested in vitro for their antimicrobial action against various strains of bacterial and fungi organisms.