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Vol. 22 No. 8 (2010): Vol 22 Issue 8

Arylnaphthalene Lignans from Daphne acutiloba Rehd.

Jing-Li Cao
School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P.R. China ; Department of Chemistry, Yuxi Teacher's College, Yuxi 653100, P.R. China
Jing-Jiao Xue
School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P.R. China ; Department of Chemistry, Yuxi Teacher's College, Yuxi 653100, P.R. China
Shun-Qin He
School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P.R. China
Guang-Yu Yang
School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P.R. China ; Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Acedemy of Tobacco Science, Kunming 650106, P.R. China.
Qiu-Fen Hu
School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, P.R. China ; Department of Chemistry, Yuxi Teacher's College, Yuxi 653100, P.R. China

Corresponding Author(s) : Qiu-Fen Hu

huqiufena@yahoo.com.cn

Asian Journal of Chemistry, Vol. 22 No. 8 (2010): Vol 22 Issue 8

Abstract

A new arylnaphthalene lignan (daphnelignan B), together with three known one, were isolated from the leaf and steam of Daphne acutiloba Rehd. Their structures were determined by means of HRESIMS, extensive 1D and 2D NMR spectroscopic studies and chemical evidence. The anti-HIV-1 activity of daphnelignan B was also evaluated and it shows an anti-HIV-1 activity with a TI (Therapeutic Index) above 35.62.

Keywords

Daphne acutiloba Rehd. Arylnaphthalene lignans Daphnelignan B Anti-HIV-1 activity
(1)
Cao, J.-L.; Xue, J.-J.; He, S.-Q.; Yang, G.-Y.; Hu, Q.-F. Arylnaphthalene Lignans from Daphne Acutiloba Rehd. ajc 2010, 22, 6509-6512.
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