Study of Synthesis of Some Pyrroloquinolines, Pyrroloisoquinolines, Pyridocarbazoles and Their Derivatives

Abstract

The new isomers of pyrroloquinolines, pyrroloisoquinolines and pyridocarbazoles have been synthesized from the hydrazone of methylisopropylketone, 2-methylcyclohexanone, 5 and 8- quinolylhydrazine and 5-isoquinolylhydrazine by ring closure in AcOH at reflux in excellent yields. The methiodide of pyrroloisoquinoline and pyridocarbazole were reduced with NaBH4 at room temperature to produce corresponding hexahydropyrroloisoquinoline and decahydropyridoisoquinoline in good yields.