Synthesis of 2-N-Salicylidene-5-(substituted)-1,3,4-thiadiazole as Potential Antimicrobial Agents

Abstract

Several new 2,5-disubstituted derivatives of 1,3,4-thiadiazoles containing imine moiety were obtained from cyclization of thiosemicarbazide and corresponding p-substituted carboxylic acid in phosphorus oxychloride then the resulted products were reacted with salicylaldehyde to give the final products 3a-h. All the newly synthesized compounds were characterized using FTIR, ¹H NMR, ¹³C NMR and elemental analysis. All compounds have been screened for their antimicrobial activity and showed that the introduction of 1,3,4-thiadiazole ring significantly increase the antibacterial activity