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A Review on Azapeptides: The Promising Peptidomimetics

https://doi.org/10.14233/ajchem.2017.20802
Arifa Begum
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati-517 502, India
D. Sujatha
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati-517 502, India
K.V.S.R.G. Prasad
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati-517 502, India
K. Bharathi
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati-517 502, India

Corresponding Author(s) : Arifa Begum

arifa.medchem@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 9 (2017): Vol 29 Issue 9

Abstract

Peptidomimetics, the mimics of natural peptides are considered as promising therapeutics with potential applications in modern medicine. Among the various structural variants of peptidomimetics that have been designed and synthesized, the azapeptides serve as the interesting peptide backbone modifications owing to their diversified biological and pharmacokinetic properties. The aim of this review is to highlight the significance of azapeptide in enhancement of stability and bioavailability, represent the various scaffolds of azapeptides as peptidomimetics, notify their significance as cysteine and serine protease inhibitors, provide an insight on the various biologically significant azapeptides and emphasize the main features on the conventional to modified synthetic strategies of azapeptides.

Keywords

Azapeptides Cysteine protease Serine protease Peptidomimetics
Begum, A., Sujatha, D., Prasad, K., & Bharathi, K. (2017). A Review on Azapeptides: The Promising Peptidomimetics. Asian Journal of Chemistry, 29(9), 1879–1887. https://doi.org/10.14233/ajchem.2017.20802
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