Microwave Synthesis and Antimicrobial Evaluation of Mannich Bases of 6-Benzoyl-2(3H)-benzothiazolone

Abstract

In this study, new eight Mannich base of 6-benzoyl-2(3H)-benzothiazolone derivatives have been synthesized in microwave irradiation. Structures of the synthesized compounds have been elucidated by IR and ¹H NMR spectral data and their elemental analyses. The in vitro antimicrobial activity of the compounds was determined against some gram positive, gram negative bacteria, fungi and their drug-resistant isolates in comparison with reference drugs. All the compounds were also screened for their antimycobacterial activity against Mycobacterium tuberculosis H37RV by using the microplate alamar blue assay (MABA) method.