Evaluation of Anticancer Activity of Some 1,3,4-Oxadiazole Derivatives Against Ehrlich ascites carcinoma Bearing Mice

Abstract

Synthesis of carboxymethyl derivatives of 1,3,4-oxadiazole-2-thione (a-e) were carried out by ring closure reaction with appropriate acid hydrazide, carbon disulfide and potassium hydroxide solution by conventional refluxing method. The attachment of an acetic acid moiety at the thiol equivalent site was tried for new biological properties. Synthesized compounds were characterized by IR, ¹H NMR studies and their anticancer activity were evaluated. Tumour cells used for anticancer activity were EAC (Ehrlich ascites carcinoma) cells originated from human breast carcinoma. Male Swiss albino mice were used as test animals. The standard drug used was cisplatin (1 mg/kg, body weight). The compound (a) showed significant inhibition of cancer cell growth as compared to others. The result of the present investigation encourage us to develop and improve similar other related compounds and test them for a wide range of biological activity.