Synthesis, Spectroscopic Studies and Antimicrobial Activity of Tetrakis(4-bromo-2- formylphenoxy)cyclotriphosphazene and its Imino-Amino Derivatives

Abstract

Tetrakis(4-bromo-2-formylphenoxy)cyclotriphosphazene (1) derived from 5-bromo-2- hydroxybenzaldehyde and hexachloro cyclotriphosphazene have been synthesized. The condensation reactions of 1 with some amines in THF have been studied. A series of Schiff bases and amino containing phosphazenes (2, 3 and 4) were isolated and characterized by elemental analysis, UV, IR, ¹H, ¹³C, ³¹P NMR and mass spectroscopy. The antimicrobial activities of these compounds have been screened in vitro against the organisms Bacillus cereus ATCC 7064, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538P, Staphylococcus epidermidis ATCC NRRL 3284, Enterobacter aerogenes ATCC 13048, Micrococcus luteus LA 2971, Proteus vulgaris ATCC 8427, Salmonella typhi ATCC 19430, Salmonella typhimurium CCM 5445, Pseudomonas aeruginosa ATCC 27853, Pseudomonas fluorescens ATCC 17400, Listeria monocytogenes ATCC 19117, Rhodotorula rubra DSM 70403, Debaryomyces hansenii DSM 70238, Hanseniaspora guilliermondii DSM 3432, Kluyveromyces fragilis NRRL 2415, Candida albicans ATCC 10231, Candida parapsilosis ATCC 90018, Candida tropicalis ATCC 13803.