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Vol. 22 No. 5 (2010): Vol 22 Issue 5

Simultaneous Determination of Drotaverine Hydrochloride and Mefenamic Acid by Isocratic RP-HPLC Method

R. Ankam
Glenmark Pharmaceuticals Ltd., R & D Centre, Plot No. C-152, M.I.D.C., Malegaon, Sinner-422 113, India
K. Mukkanti
Centre for Environment IPGSR, JNT University, Hyderabad-500 028, India.
S. Durgaprasad
Indian Immunologicals Ltd., Rakshapuram, Gachibowli, Hyderabad-500 019, India
P.V.L. Naidu
Glenmark Pharmaceuticals Ltd., R & D Centre, Plot No. C-152, M.I.D.C., Malegaon, Sinner-422 113, India

Corresponding Author(s) : R. Ankam

ankam_1999@yahoo.com

Asian Journal of Chemistry, Vol. 22 No. 5 (2010): Vol 22 Issue 5

Abstract

A simple fast, accurate, precise and cost effective isocratic RP-HPLC method is developed for simultaneous determination of drotaverine hydrochloride and mefenamic acid. The retention times of drotaverine hydrochloride and mefenamic acid were found to be 3.05 and 9.52 min, respectively. The method was linear over the range of 16 to 47 ppm with r2 = 0.9999 for drotaverine hydrochloride and 100 to 300 ppm with r2 = 0.9999 for mefenamic acid. Mean recovery for drotaverine hydrochloride and mefenamic acid were 101.1 and 101.2, respectively.

Keywords

Mefenamic acid Drotaverine hydrochloride RP-HPLC
Ankam, R., Mukkanti, K., Durgaprasad, S., & Naidu, P. (2010). Simultaneous Determination of Drotaverine Hydrochloride and Mefenamic Acid by Isocratic RP-HPLC Method. Asian Journal of Chemistry, 22(5), 3629–3634. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11592
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