In Vitro Antioxidant Activity Evaluation of 4-Methyl Coumarin Derivatives

Abstract

We have screened a number of heterocyclic compounds (4-methyl-coumarins) bearing different functionalities such as hydroxy, acetoxy and propoxy in combination with carboxylic acid group at different positions in the benzenoid ring of the coumarin nucleus for their effect on NADPH catalyzed liver microsomal lipid peroxidation and radical scavenging activity using diphenyl picryl hydrazyl (DPPH) with a view to make the structure activity relationship (SAR). Compounds 5, 6, 7 and 8 showed excellent in vitro inhibition of NADPH catalyzed lipid peroxidation and DPPH radical scavenging activity.