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Vol. 29 No. 8 (2017): Vol 29 Issue 8

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FT-Raman Spectroscopy with Chemometric Methods for Quantification of Lamivudine Form II in Lamivudine Form I

https://doi.org/10.14233/ajchem.2017.20600
M. Chandra Sekhara Rao
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India; Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515 002, India
R. Chenna Krishna Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India; Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515 002, India
K.B. Chandra Sekhar
Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515 002, India
Y.V. Rami Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India

Corresponding Author(s) : Y.V. Rami Reddy

dryvrsvu@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 8 (2017): Vol 29 Issue 8

Abstract

Lamivudine is known to exhibit polymorphism and the needle-shaped crystals are named as Form I and the bipyramidal crystals as Form II. The FT-Raman spectrum of lamivudine Form II and I shows characteristic bands at 798, 463 cm-1 and 697 cm-1 Raman shifts, respectively. FT-Raman spectroscopy method combined with chemometrics was developed for quantitative analysis of lamivudine Form II in lamivudine Form I drug substance. Solid mixtures of Form I and Form II shows the relative intensity of the characteristic bands at 798, 463 and 697 cm-1 were proportional to the relative amounts of Form I and Form II in mixtures. A calibration was made which is linear in the range from 1.0 to 20.0 % (w/w) of Form II in Form I. The results indicate that levels down to 3.0 % (w/w) of Form II could be quantified using this non-destructive approach, with less than 1.5 % (w/w) limit of detection.

Keywords

Lamivudine drug Polymorphism FT-Raman spectroscopy Chemometrics Calibration Limit of detection Limit of quantification
Sekhara Rao, M. C., Krishna Reddy, R. C., Sekhar, K. C., & Reddy, Y. R. (2017). FT-Raman Spectroscopy with Chemometric Methods for Quantification of Lamivudine Form II in Lamivudine Form I. Asian Journal of Chemistry, 29(8), 1735–1742. https://doi.org/10.14233/ajchem.2017.20600
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