Assessment of Thermal Stability of Metformin Hydrochloride
Corresponding Author(s) : Vipin K. Sharma
sharma_dibru@yahoo.co.in
Asian Journal of Chemistry,
Vol. 22 No. 5 (2010): Vol 22 Issue 5
Abstract
Metformin hydrochloride is a drug of choice of biguanide category in the management of diabetes mellitus. The drug sample was scanned for λmax by spectrophotometer and also by HPLC. The FTIR spectrum of the sample drug was compared with reference for genuinety. The thermal stability of the drug was studied at 30, 40, 50 and 70 ºC in aqueous medium as it is freely soluble in water. The data obtained was treated by Arrhenius, zero order and first order kinetics. Metformin followed zero order kinetics in thermal degradation and covered 208 h to be decomposed up to 10 %.
Keywords
Metformin hydrochloride
Thermal stability
Arrhenius plot
K. Sharma, V., Nautiyal, V., K. Goel, K., & Sharma, A. (2010). Assessment of Thermal Stability of Metformin Hydrochloride. Asian Journal of Chemistry, 22(5), 3561–3566. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11582
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