Synthesis and Antimicrobial Activity of Schiff Bases Derived from 2-Formylphenoxy Acetic Acid

Abstract

A series of seven Schiff bases were synthesized by reacting 2-formyl-phenoxy acetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of IR and ¹H NMR. The compounds were assayed by the disc diffusion method for antibacterial activity against Staphylococcus aureus and Escherichia coli. Among the compounds tested, V₁, V₃, V₄ and V₆, exhibited good antibacterial activity, almost equal to that of ampicillin used as standard drug.