Synthesis of Some Pramoxine-Based Compounds as Possible Local Anesthetic and Anticholinergic Agents

Abstract

A pair of pramoxine-based compounds, K-94 and K-95, which are potential local anesthetic and anticholinergic agents, were synthesized using a previously synthesized Schiff base of 2-diethylamine chloride and potassium carbonate. Of the compounds synthesized, compound K-94 was new. Moreover, R_M, a physicochemical parameter, has been calculated for both compounds in order to investigate the effect of these structural changes on the lipophilic and steric characteristics of these molecules. It also provides relevant data for the correlations with structure-activity relationship studies. Both of these compounds, phenylimino derivative, K-94, having an R_M of 0.91 and phenethylimino derivative, K-95, having an R_M of 0.87, showed similar values with procaine having R_M value of 0.66.