Bromodimethyl Sulphonium Bromide Catalyzed Efficient One Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones: An Improved High Yielding Simple Protocol for The Biginelli Reaction
Corresponding Author(s) : B. Sunil Kumar
sunil_bal1@yahoo.co.in
Asian Journal of Chemistry,
Vol. 22 No. 5 (2010): Vol 22 Issue 5
Abstract
A novel one pot cyclocondensation of aldehyde, β-ketoester and urea or thiourea in acetonitrile by using bromodimethyl sulphonium bromide (BSB) under mild conditions affording 3,4- dihydropyrimidine-2-(1H) ones in excellent yield is described.
Keywords
Dihydropyrimidinones
Bromodimethyl sulphonium bromide
β-Ketoesters
Biginelli reaction
D. Bhinge, S., Saifuddin Khalid, M., & Sunil Kumar, B. (2010). Bromodimethyl Sulphonium Bromide Catalyzed Efficient One Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones: An Improved High Yielding Simple Protocol for The Biginelli Reaction. Asian Journal of Chemistry, 22(5), 3381–3384. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11558
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