Bromodimethyl Sulphonium Bromide Catalyzed Efficient One Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones: An Improved High Yielding Simple Protocol for The Biginelli Reaction
Corresponding Author(s) : B. Sunil Kumar
sunil_bal1@yahoo.co.in
Asian Journal of Chemistry,
Vol. 22 No. 5 (2010): Vol 22 Issue 5
Abstract
A novel one pot cyclocondensation of aldehyde, β-ketoester and urea or thiourea in acetonitrile by using bromodimethyl sulphonium bromide (BSB) under mild conditions affording 3,4- dihydropyrimidine-2-(1H) ones in excellent yield is described.
Keywords
Dihydropyrimidinones
Bromodimethyl sulphonium bromide
β-Ketoesters
Biginelli reaction
(1)
D. Bhinge, S.; Saifuddin Khalid, M.; Sunil Kumar, B. Bromodimethyl Sulphonium Bromide Catalyzed Efficient One Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-Ones: An Improved High Yielding Simple Protocol for The Biginelli Reaction. ajc 2010, 22, 3381-3384.
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