Spectrophotmetric Determination of Cefpodoxime Proxetil in Tablets

Abstract

A new simple spectrophotometric method for the assay of cefpodoxime proxetil (CEFP) has been described. Haematoxylin, [7,11-b-dihydrobenz-b-indeno-(1,2-d)-pyran-3,4,6a,9,10-6(h)- pentol] is a catechol derivative from the log wood (haematoxylin campeachianum), when treated with an oxidizing agent, undergoes oxidation to yield haematin. The colour species formation may be attributed to the formation of charge transfer complex between in situ formed haematin from haematoxylin-chtoramine-T (CAT) and -S:-portion in cefpodoxime proxetil. The λ_max was at 555 nm. The proposed method is selective, simple and accurate. The results obtained are reproducible and statistically validated.