Comparative X-Ray Diffraction Studies of Indomethacin Solid Dispersions

Abstract

This study focuses on comparative investigation of solid dispersion system consisting of drug and carrier in fresh as well as after storage at elevated temperature. Solid dispersions of a waterinsoluble indomethacin with different water soluble carriers namely urea, mannitol, sucrose and dextrose were prepared. The samples were stored at a temperature of 40 ± 1 ºC for 2 months and results of X-ray diffractograms of fresh samples as well stored samples were compared. Samples of solid dispersion of mannitol-sucrose-indomethacin and mannitol-dextrose-indomethacin showed increased crystallinity.