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Vol. 22 No. 4 (2010): Vol 22 Issue 4

New Strategy for the Synthesis of Telmisartan: An Antihypertensive Drug

S. Venugopal
Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad-500 049, India
J. Ramanatham
Department of Chemistry, AstraZeneca, Bangalore-560 024, India.
N. Devanna
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur-515 002, India.
A. Sanjeev Kumar
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
Samir Ghosh
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
R. Soundararajan
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
Bhima Kale
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
G.N. Mehta
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India

Corresponding Author(s) : R. Soundararajan

soundara1959@rediffmail.com

Asian Journal of Chemistry, Vol. 22 No. 4 (2010): Vol 22 Issue 4

Abstract

An improved, convergent and industrially useful process suitable for large-scale production of telmisartan has been described. The key steps are Suzuki coupling for the preparation of key intermediate 4,4-dimethyl-2-(4'-methanesulfonyloxy methylbiphenyl-2-yl)oxazoline of telmisartan, N-alkylation and oxazoline hydrolysis.

Keywords

Telmisartan Antihypertensive drug Suzuki coupling and Oxazoline hydrolysis
(1)
Venugopal, S.; Ramanatham, J.; Devanna, N.; Sanjeev Kumar, A.; Ghosh, S.; Soundararajan, R.; Kale, B.; Mehta, G. New Strategy for the Synthesis of Telmisartan: An Antihypertensive Drug. ajc 2010, 22, 2767-2773.
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