New Strategy for the Synthesis of Telmisartan: An Antihypertensive Drug
Corresponding Author(s) : R. Soundararajan
soundara1959@rediffmail.com
Asian Journal of Chemistry,
Vol. 22 No. 4 (2010): Vol 22 Issue 4
Abstract
An improved, convergent and industrially useful process suitable for large-scale production of telmisartan has been described. The key steps are Suzuki coupling for the preparation of key intermediate 4,4-dimethyl-2-(4'-methanesulfonyloxy methylbiphenyl-2-yl)oxazoline of telmisartan, N-alkylation and oxazoline hydrolysis.
Keywords
Telmisartan
Antihypertensive drug
Suzuki coupling and Oxazoline hydrolysis
Venugopal, S., Ramanatham, J., Devanna, N., Sanjeev Kumar, A., Ghosh, S., Soundararajan, R., … Mehta, G. (2010). New Strategy for the Synthesis of Telmisartan: An Antihypertensive Drug. Asian Journal of Chemistry, 22(4), 2767–2773. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11474
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