Reaction of 4-Amino-4,5-Dihydro-1H-1,2,4-Triazol-5-one with Some Carboxylic Acid Anhydrides and their Antiinflammatory Activity
Corresponding Author(s) : R.J. Singh
singhram@iocl.co.in ; drrjsinghtdc@rediffmail.com
Asian Journal of Chemistry,
Vol. 22 No. 4 (2010): Vol 22 Issue 4
Abstract
Syntheses of a series of 3-alkyl(aryl)-4-tetrachlorophthalimido-4,5- dihydro-1H-1,2,4-triazol- 5-ones and 3-alkyl(aryl)-4-(1,8-naphthalimido-4,5- dihydro)-1H-1,2,4-triazol-5-ones are described. The newly compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antiinflammatory activity. All the compounds carring 1,2,4- triazole moiety showed significant antiinflammatory activity.
Keywords
1,2,4-Triazolones
Tetrachlorophthalic anhydride
1,8-Naphthalic anhydride
Singh, R., & Singh, D. (2010). Reaction of 4-Amino-4,5-Dihydro-1H-1,2,4-Triazol-5-one with Some Carboxylic Acid Anhydrides and their Antiinflammatory Activity. Asian Journal of Chemistry, 22(4), 2664–2668. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11459
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