Pseurotin A: An Antibacterial Secondary Metabolite from Aspergillus fumigatus

Abstract

Bioassay guided fractionation of a chloroform extract of Aspergillus fumigatus culture afforded pseurotin A (1). The compound was identified by a series of spectral data including 1D/2D NMR and MS analyses. The extract and pseurotin A (1) showed mild to moderate antimicrobial activity against a panel of gram +ve and gram -ve bacteria and a fungus. The minimum inhibitory concentration of 1 was found to be 64 μg/mL against the most susceptible, Bacilus cereus and Shigella shiga.