The present work reveals that lead acetate treated 160 mg/kg, kidney showed revealing areas of haemorrhages, atrophic glomerular tufts, tubular epithelial cells revealing degenerative changes. Methanolic extract of Leucas aspera treated 100 mg/kg kidney showed mild focal haemorrhages with almost normal appearance of the glomeruli and mild degenerative changes in the tubular epithelial cells. Standard (silymarin) treated 140 mg/kg kidney showed revealing normal glomerular architecture and very mild changes in the tubular epithelial cells. Lignans isolated from methanolic extract of Leucas aspera may be useful as nephroprotective agent.
Soma Sekhar Reddy, K., Padmanabha Reddy, Y., Ravindra Reddy, J., Ramesh, B., Srirama Chandra, M., Pradeep Kumar, B., & Sandhya Rani, P. (2010). Effect of Leucas aspera on Lead Acetate Induced Nephrotoxicity in Rats. Asian Journal of Chemistry, 22(3), 2450–2452. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11420
