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Vol. 22 No. 3 (2010): Vol 22 Issue 3

New Strategy for the Synthesis of (±) Cherylline Dimethyl Ether

S. Venugopal
Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, India
J. Ramanatham
Department of Chemistry, AstraZeneca Research Foundation India, Bangalore-560 024, India
N. Devanna
Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, India
A. Sanjeev Kumar
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
Samir Ghosh
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
R. Soundararajan
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
Bhima Kale
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India
G.N. Mehta
Chemistry Section, Applied Sciences and Humanities Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India

Corresponding Author(s) : R. Soundararajan

soundara1959@rediffmail.com

Asian Journal of Chemistry, Vol. 22 No. 3 (2010): Vol 22 Issue 3

Abstract

A concise route for the synthesis of (±) cherylline dimethyl ether is reported. The key steps involved are Grignard addition of 3,4-dimethoxy benzene magnesium bromide to the p-methoxy nitrostyrene, reduction of nitro intermediate followed by Pictet-Spangler cyclization.

Keywords

Grignard reaction Reduction Tetrahydroisoquinolines Pictet-Spangler cyclization
Venugopal, S., Ramanatham, J., Devanna, N., Sanjeev Kumar, A., Ghosh, S., Soundararajan, R., … Mehta, G. (2010). New Strategy for the Synthesis of (±) Cherylline Dimethyl Ether. Asian Journal of Chemistry, 22(3), 1835–1840. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11343
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