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Vol. 29 No. 8 (2017): Vol 29 Issue 8

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Design, Microwave Assisted Synthesis and Characterization of Substituted 1,2,4-Oxadiazole Analogues as Promising Pharmacological Agents

https://doi.org/10.14233/ajchem.2017.20626
Katharigatta N. Venugopala
Department of Biotechnology and Food Technology, Durban University of Technology, Steve Biko Campus, Durban 4001, South Africa

Corresponding Author(s) : Katharigatta N. Venugopala

katharigattav@dut.ac.za

Asian Journal of Chemistry, Vol. 29 No. 8 (2017): Vol 29 Issue 8

Abstract

Microwave assisted synthesis of a series of 3,5-disubstituted-1,2,4-oxadiazole analogues (3a-j) has been achieved between 5-(chloromethyl)-3-substituted phenyl-1,2,4-oxadiazoles (2a-j) and substituted benzophenone in presence of potassium carbonate in acetone medium. The structural elucidation of the newly synthesized 1,2,4-oxadiazole analogues was established by means of FT-IR, NMR, LC-MS and elemental analysis.

Keywords

Microwave assisted synthesis 1,2,4-Oxadiazoles Pharmacological properties
Venugopala, K. N. (2017). Design, Microwave Assisted Synthesis and Characterization of Substituted 1,2,4-Oxadiazole Analogues as Promising Pharmacological Agents. Asian Journal of Chemistry, 29(8), 1767–1770. https://doi.org/10.14233/ajchem.2017.20626
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