Synthesis of Some Derivatives of 4,5-Dihydrooxazoles

Abstract

Benzaldehyds with sodium amide in the presence of thiourea in tetrahydro furan at room temperature gave various 2,4,5-triphenyl-4,5-dihydrooxazoles. The thiourea-catalyzed condensation of the benzaldehyde yielded 2-amino-1,2-diphenylethanone. Reduction of 2-amino-1,2- diphenylethanone was performed with hydride from Cannizzaro reaction to give 2-amino-1,2- diphenylethanols. The 4,5-dihydrooxazole ring formation of the 2-amino-1,2-diphenylethanol and benzamide gave the desired 4,5-dihydrooxazole.