Spectrophotometric Determination of Amlodipine Besylate Using 2-Hydroxynaphthaldehyde as a Derivatizing Reagent
F. Almani
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
F.M.A. Rind
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan ; Dr. M.K. Kazi Institute of Chemistry, Faculty of Natural Sciences, University of Sindh, Jamshoro, Pakistan.
A.H. Memon
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
U.R. Mughal
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
M.G.H. Laghari
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
N. Memon
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
M.L. Maheshwari
Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
M.Y. Khuhawar
Dr. M.K. Kazi Institute of Chemistry, Faculty of Natural Sciences, University of Sindh, Jamshoro, Pakistan.
Corresponding Author(s) : F.M.A. Rind
mahboobalirind@yahoo.com
Asian Journal of Chemistry,
Vol. 22 No. 2 (2010): Vol 22 Issue 2
A new spectrophotometric method has been developed for the determination of the amlodipine besylate by derivatization with 2-hydroxy-naphthaldehyde. The molar absorptivity of amlodipine besylate after derivatization was calculated 1.05 ×104 L mol–1 cm–1 at λmax 416 nm. The derivative obeyed the Beer’s law within the concentration range 4-20 μg/mL. The color reaction was highly stable and did not show any change in absorbance up to 12 h. The method was applied for the analysis of amlodipine besylate from tablets of various pharmaceutical companies and the amounts found were observed within 2.48, 4.95 and 9.97 mg/tablet with relative standard deviations (RSD) ranging 2.7-0.01 % (n = 3), respectively.
Almani, F., Rind, F., Memon, A., Mughal, U., Laghari, M., Memon, N., … Khuhawar, M. (2010). Spectrophotometric Determination of Amlodipine Besylate Using 2-Hydroxynaphthaldehyde as a Derivatizing Reagent. Asian Journal of Chemistry, 22(2), 1205–1213. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11251
