Synthesis and Evaluation of Substituted Cinnamoyl Alanines for Antiinflammatory, Analgesic and Antioxidant Activities

Abstract

A series of substituted cinnamoyl alanines were synthesized by condensation of substituted 4- benzylidene-2-phenyloxazol-5-ones with alanine. The chemical structures of synthesized compounds were confirmed by means of IR, ¹H NMR, mass spectral and elemental analysis. All the compounds were screened for their antiinflammatory, analgesic and antioxidant activities. Out of these compounds, N-[2-(benzoylamino)-3-(3,5-dimethoxy-4-hydroxyphenyl)-1-oxo-2- propenyl]alanine (24) exhibited good antiinflammatory activity (70 %) comparable to the standard drug phenylbutazone (73 %). This compound also showed good analgesic activity. Several phenolic compounds in this series showed good antioxidant activity.