Synthesis of Biologically Active N-Substituted 4-biphenyl Acetamide Derivatives

Abstract

A number of N-substituted (4-biphenyl)amides have been synthesized by condensation of 4-biphenyl acetic acid (4-BPAA) with SOCl₂ in dry benzene to prepare 4-biphenyl acetyl chloride. 4-Biphenyl acetyl chloride is then treated with different amides having one replaceable hydrogen (–CONH₂) to form new variety of amides (–CO–NH–CO–). The structure of newly synthesized compounds have been established by analytical and spectral methods.