Microwave Promoted Solvent-Free Biginelli Reaction for the One Pot Synthesis of Dihydropyrimidin-2-(1H)-ones Catalyzed by Sulfamic Acid
Corresponding Author(s) : Nandini Pai
nandini_pai@hotmail.com
Asian Journal of Chemistry,
Vol. 23 No. 12 (2011): Vol 23 Issue 12
Abstract
An efficient synthesis of 3,4-dihydropyrimidinones (DHPMS) using sulfamic acid as catalyst from an aldehyde, β-keto ester, urea and thiourea under the conventional heating and solventfree microwave irradiations is described. The solvent-free microwave assisted green procedure offer advantages such as shorter reaction times, simple work-up, excellent yield over the conventional heating.
Keywords
Biginelli reaction
Sulfamic acid
Ethyl acetoacetate
Microwave-irradiation
3,4-Dihydropyrimidin-2(1H)- ones
(1)
Pai, N.; Waghmode, K.; Khandekar, D. Microwave Promoted Solvent-Free Biginelli Reaction for the One Pot Synthesis of Dihydropyrimidin-2-(1H)-Ones Catalyzed by Sulfamic Acid. ajc 2011, 23, 5217-5219.
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