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Vol. 29 No. 7 (2017): Vol 29 Issue 7

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Kinetics and Mechanism of Reaction of cis-[Cr(C2O4)2(H2O)2]– with L-Dopa in Aqueous Medium: A Comparative Antiparkinsonian Studies

https://doi.org/10.14233/ajchem.2017.20573
Sudhanshu Sekhar Rout
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 030, India
Durga Madhab Kar
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 030, India
Sovan Pattanaik
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 030, India
Sudam Chandra Si
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 030, India
Prakash Mohanty
Department of Chemistry, Ravenshaw University, Cuttack-753 003, India

Corresponding Author(s) : Sudhanshu Sekhar Rout

sudhanshurout@soauniversity.ac.in

Asian Journal of Chemistry, Vol. 29 No. 7 (2017): Vol 29 Issue 7

Abstract

The substitution reaction of cis-[Cr(C2O4)2(H2O)2]- with L-Dopa in aqueous medium has been studied over the range 35 £ t £ 50 °C, 3.5 £ pH £ 6.0, 5.0 × 10-3 mol dm-3 £ [L-Dopa] £ 15 × 10-3 mol dm-3, I = 0.1 mol dm-3 (KNO3). The reaction takes place via an outer sphere association between cis-[Cr(C2O4)2(H2O)2]- and L-Dopa followed by chelation. Characterization of the product was done by physico-chemical and infrared spectroscopic methods. The antiparkinsonian activity of L-Dopa was found to be less than that of the product chromium(III) complex.

Keywords

Kinetics and mechanism Substitution cis-Diaqua-bis(oxalato)chromate(III) L-Dopa Antiparkinsonian drug
Rout, S. S., Kar, D. M., Pattanaik, S., Si, S. C., & Mohanty, P. (2017). Kinetics and Mechanism of Reaction of cis-[Cr(C2O4)2(H2O)2]– with L-Dopa in Aqueous Medium: A Comparative Antiparkinsonian Studies. Asian Journal of Chemistry, 29(7), 1555–1560. https://doi.org/10.14233/ajchem.2017.20573
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