Synthesis, Characterization and in vitro Antimicrobial Activity of Co(II), Cu(II), Zn(II), Cd(II) and Sn(II) Ions with {[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]thio}acetic Acid

Abstract

In present studies, five metal complexes derivative of {[5-(4-bromophenyl)-1,3,4-oxadiazol-2- yl]thio}acetic acid, HL with the metal ions [Co(II), Cu(II), Zn(II), Cd(II) and Sn(II)] have been successfully prepared in alcoholic medium. The complexes obtained are characterized quantitatively and qualitatively by using FTIR spectroscopy, electronic spectroscopy, mass spectroscopy ¹H and ¹³C NMR, magnetic susceptibility and conductivity measurements. From the spectral study, all the complexes obtained as a monomeric structure and the metals centre moieties are four-coordinated and exhibited tetrahedral geometry except Cu(II) complex (square planar). Preliminary in vitro antimicrobial study indicated that all the compounds showed significant activity against the tested bacterial strains.