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Vol. 23 No. 11 (2011): Vol 23 Issue 11

Synthesis of Water-Soluble Prodrug of Florfenicol

G.C. Qin
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
L.X. Chen
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
P. Yang
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P.R. China
H. Zuo
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P.R. China
Z.B. Li
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P.R. China

Corresponding Author(s) : Z.B. Li

zb63@163.com

Asian Journal of Chemistry, Vol. 23 No. 11 (2011): Vol 23 Issue 11

Abstract

Water-soluble prodrug of florfenicol was synthesized by introducing a water-soluble small moiety to the hydroxyl of florfenicol according to the prodrug design principles. The water-solubility of the prodrug was about 500 times higher than florfenicol and the water soluble prodrug of forfenicol displays high aqueous solubility and is stable in water as well as in organic solvents.

Keywords

Florfenicol Prodrug Synthesis DMAP Esterification
Qin, G., Chen, L., Yang, P., Zuo, H., & Li, Z. (2011). Synthesis of Water-Soluble Prodrug of Florfenicol. Asian Journal of Chemistry, 23(11), 5157–5158. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/11060
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