Synthesis of Pyridinecarbothionylaminopyridines and Conversion of Thioamide to Amide

Abstract

Pyridinecarbothionylaminopyridines as structural isomers were obtained by the reactions of 2,3-and 2-4-lutidine with aminopyridines and sulfur. Reaction of 2,6-lutidine with active methyl group anilines in the presence of sulfur gave the desired thioamides 5. Reaction of synthesized thioamides 5 with sulfur and SiO₂ or SeO₂ gave the corresponding amide 6. We now report conversion of thioamide to amide by using oxidizing inorganic reagent.