Thermodynamic Properties of Matrine in Citric Acid Solution

Abstract

The enthalpies of dissolution of matrine in citric acid solution (0.15 mol L^-1) were measured using a RD496-2000 Calvet Microcalorimeter at 309.65 K under atmospheric pressure. The differential enthalpy (Δ_difH_m) and molar enthalpy (Δ_solH_m) of dissolution of matrine in citric acid solution (0.15 mol L^-1) were determined. The corresponding kinetic equation described the dissolution process was elucidated to be  . Moreover, the half-life, Δ_solH_m, Δ_solG_m and Δ_solS_m of the dissolution process were also obtained. This work will provide a potential reference for the clinical application of matrine.