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Vol. 29 No. 7 (2017): Vol 29 Issue 7

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Estimation of Ethanol in Marketed Mouthwashes by Gas Chromatography

https://doi.org/10.14233/ajchem.2017.20594
M. Marvania
SVKM's NMIMS School of Pharmacy & Technology Management, Mukesh Patel Technology Park, Babulde Banks of Tapi River, Mumbai-Agra Road, Shirpur-425 405, India
S. Deshpande
SVKM's NMIMS School of Pharmacy & Technology Management, Mukesh Patel Technology Park, Babulde Banks of Tapi River, Mumbai-Agra Road, Shirpur-425 405, India
S. Bagade
SVKM's NMIMS School of Pharmacy & Technology Management, Mukesh Patel Technology Park, Babulde Banks of Tapi River, Mumbai-Agra Road, Shirpur-425 405, India
M. Shelke
SVKM's NMIMS School of Pharmacy & Technology Management, Mukesh Patel Technology Park, Babulde Banks of Tapi River, Mumbai-Agra Road, Shirpur-425 405, India

Corresponding Author(s) : S. Deshpande

shirishdeshpande5@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 7 (2017): Vol 29 Issue 7

Abstract

The present study was oriented towards gas chromatographic estimation of alcohol, as a quality control process. The determination of ethanol in alcoholic mouthwash is very essential to maintain the quality and efficacy. In this study simple and rapid gas chromatographic method was developed for determination of ethanol in mouthwash using packed column (15 % FFAP, 2 m × 0.125 inch) with detection by flame ionization detector (FID). The retention time of alcohol was found to be less than 6 min. The estimate of the standard deviation of the chromatography for duplicate injections is ± 0.02 %. This gas chromatography method determines ethanol separately from the other components of mouthwash that interfere in detection method and without distillation or chemical reaction. When large numbers of samples are analyzed, it reduces analysis time per sample and with adequate accuracy of estimation. The developed method was validated with various validation parameters viz. accuracy, precision, ruggedness, robustness and could be one of the rapid methods for quality control analysis of alcohol containing mouthwashes.

Keywords

Gas Chromatography Mouth wash ethanol
Marvania, M., Deshpande, S., Bagade, S., & Shelke, M. (2017). Estimation of Ethanol in Marketed Mouthwashes by Gas Chromatography. Asian Journal of Chemistry, 29(7), 1587–1590. https://doi.org/10.14233/ajchem.2017.20594
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