Synthesis of Novel Chitosan Derivatives

Abstract

Novel chitosan derivatives 2-[4-(2-fluorobenzylideneamino)pyridyl]acetyl chitosan chloride (FBPACS), 2-[4-(2-chlorobenzylideneamino)-pyridyl]acetyl chitosan chloride (CBPACS), 2- [4-(2-bromobenzylideneamino)pyridyl]acetyl chitosan chloride (BBPACS), 2-[4-(2,4- dichlorobenzylideneamino)pyridyl]acetyl chitosan chloride (DCBPACS) and 2-[4-(2,4- difluorobenzylideneamino)pyridyl]acetyl chitosan chloride (DFBPACS) were prepared. The structures of the derivatives were confirmed by Fourier transform infrared and ¹³C nuclear magnetic resonance. These novel chitosan derivatives were expected to have potent biological activities due to the halo-benzaldehyde condensation 4-aminopyridine Schiff base structure in their molecules.