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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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A Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles

https://doi.org/10.14233/ajchem.2019.22161
Manoj Kumar
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134003, India
Shashi Sharma
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134003, India
Hardeep Singh Tuli
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, India
Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala- 133207, India
Vinit Parkash
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134003, India

Corresponding Author(s) : Manoj Kumar

manojraju27@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

It has been discovered that ferrocenyl substituted heterocyclic compounds have wide scope of restorative methodology. The combination of ferrocenyl substituted pyrazole is the new class in these compounds with upgraded natural activity. This work center around blend of ferrocenyl substituted pyrazoles through novel course. The combination of 1-phenyl-3-ferrocenyl-pyrazole was examined including addition-cyclocondensation like response conditions. The response continued through three phases using of expansion cyclo-buildup of acetyl ferrocene with phenyl hydrazine pursued by cyclizing reagent iodine with NaHCO3. In both syntheses, each time single product isolated having good yields (87 and 79 %). Ferrocenyl substituted pyrazoles were examined by spectroscopic techniques (1H NMR, IR, MS) and their biological properties have been screened.

Keywords

Ferrocenyl substituted pyrazoles Addition cyclo-condensation Biological activities
Kumar, M., Sharma, S., Tuli, H. S., Khare, R., & Parkash, V. (2019). A Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles. Asian Journal of Chemistry, 31(12), 2729–2732. https://doi.org/10.14233/ajchem.2019.22161
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