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Vol. 29 No. 7 (2017): Vol 29 Issue 7

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Synthesis and Characterization of Imidazo[1,2-a]pyridines and Zolimidine

https://doi.org/10.14233/ajchem.2017.20533
Narva Deshwar Kushwaha
Jubilant Chemsys Ltd., B-34, Sector-58, Noida-201 301, India; NIMS University, Shobha Nagar, Jaipur-303 121, India
Somnath Mondal
Jubilant Chemsys Ltd., B-34, Sector-58, Noida-201 301, India
Renu Sharma
NIMS University, Shobha Nagar, Jaipur-303 121, India
Naresh Kumar
Jubilant Chemsys Ltd., B-34, Sector-58, Noida-201 301, India

Corresponding Author(s) : Narva Deshwar Kushwaha

narvadeshwarkushwaha@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 7 (2017): Vol 29 Issue 7

Abstract

A convenient and efficient synthesis, without any organic solvent or catalyst is described for the preparation of imidazo[1,2-a]pyridine derivatives. The reaction has been done between 2-aminopyridines and a-bromoacetone derivatives in good to excellent yields in water. In several cases the isolation does not require any chromatography for purification. The reaction thus developed has been applied for quick synthesis of zolimidine with 91 % yield.

Keywords

Imidazo[1,2-a]pyridine 2-Aminopyridines a-Bromoacetone Zolimidine
Kushwaha, N. D., Mondal, S., Sharma, R., & Kumar, N. (2017). Synthesis and Characterization of Imidazo[1,2-a]pyridines and Zolimidine. Asian Journal of Chemistry, 29(7), 1495–1498. https://doi.org/10.14233/ajchem.2017.20533
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