Synthesis and Antibacterial Activity of Some Pyrimidines Containing β-Lactams

Abstract

1-[4-(4-Methylpiperazin-1-yl)phenyl]ethanone on condensation with aryl aldehydes afforded 1-[4-(4-methylpiperazin-1-yl)phenyl]-3-substituted phenyl prop-2-en-1-one (1a-e) in good yields, which underwent cyclization with guanidine hydrochloride (2) furnished 4-[4-(4-methylpiperazin- 1-yl) phenyl]-6-substituted phenyl pyrimidin-2-amine (3a-e) followed by condensation of (3ae) with benzaldehyde (4) yielded N-benzylidene-4-[4-(4-methylpiperazin-1-yl) phenyl]-6-substituted phenyl pyrimidin-2-amine (5a-e). The cyclo condensation of compound (5a-e) with chloro acetyl chloride (6) in presence of triethylamine gave 3-chloro-1-[4-(4-(4-methylpiperazin- 1-yl) phenyl]-6-substituted phenyl pyrimidin-2-yl)-4-phenylazetidin-2-one (7a-e). The structures of these pyrimidines were established by spectral data. All the new compounds have been screened for their antibacterial activity.