Kinetics and Oxidation of 3,5-Dimethyl-2,6-diaryl piperidin-4-one Oximes by Pyridinium Chlorochromate
Corresponding Author(s) : S. Santhi
Asian Journal of Chemistry,
Vol. 23 No. 10 (2011): Vol 23 Issue 10
Abstract
Kinetics of oxidation of 3,5-dimethyl-2,6-diaryl piperidin-4-one oximes by pyridinium chlorochromate have been studied in aqueous acetic acid medium. The oxidation is first order each in [oxidant] and [substrate]. The reactions are acid catalyzed. The effect of ionic strength on the reaction rate is negligible. The reaction rates are accelerated by increasing the dielectric strength of the medium indicating a polar mechanism. The reactions are followed at four different temperatures and the activation parameters computed. Based on the results obtained a plausible mechanism is proposed. The reactivity sequence is: For para substituted aryl compounds = H > 4-Cl > 4-Me > 4-OMe; For ortho substituted aryl compounds = H > 2-Me > 2-OMe > 2-Cl.
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