Synthesis of Chalcone Thiosemicarbazones Under Ultrasound Irradiation

Abstract

A novel and efficient method to synthesize chalcone thiosemicarbazones was developed. Thiosemicarbazones were obtained in 76-93 % yields from the reactions of chalcones with thiosemicarbazide hydrochloride in presence of sodium acetate using dehydrated ethanol as solvent under ultrasound irradiation for 1.5-2.0 h at room temperature. Compared with the method of synthesis of chalcone thiosemicarbazones from chalcones and thiosemicarbazide catalyzed by acid under refluxing condition. The main advantages of this present procedure are milder conditions, higher yields and shorter reaction time.