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Vol. 23 No. 9 (2011): Vol 23 Issue 9

Interactions of Daphnodorin B and Daphentin with Calf Thymus DNA

Qiang Li
Department of Chemistry, Nanchang University, Nanchang 330031, P.R. China
Yanying Yu
Department of Chemistry, Nanchang University, Nanchang 330031, P.R. China ; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P.R. China
Shuwen Cao
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P.R. China

Corresponding Author(s) : Yanying Yu

yuyanying@ncu.edu.cn

Asian Journal of Chemistry, Vol. 23 No. 9 (2011): Vol 23 Issue 9

Abstract

The interactions of daphnodorin B and daphentin with calf thymus DNA (ctDNA) were investigated. The binding constants of daphnodorin B and daphentin with ctDNA were obtained by UV spectroscopy. Further, the binding mechanisms on the reaction of the two compounds with ctDNA and effect of ionic strength on the fluorescence property of the system have also been investigated. The results of the assay indicate that daphnodorin B intercalates with ctDNA while daphentin interacts with ctDNA by groove binding. And the binding constants of daphnodorin B and daphentin with ctDNA were 3.261 × 105 and 1.063 × 104 L mol-1, respectively.

Keywords

Daphnodorin B Daphentin Calf thymus DNA Binding
Li, Q., Yu, Y., & Cao, S. (2011). Interactions of Daphnodorin B and Daphentin with Calf Thymus DNA. Asian Journal of Chemistry, 23(9), 4138–4144. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10835
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