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Vol. 23 No. 9 (2011): Vol 23 Issue 9

Synthesis of Novel Imidazolidine-2,4-dione Derivatives as Potential Antidiabetic Agents

Xian-Chao Cheng
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Su-Xia Sun
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Hao Zhang
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Wei-Li Dong
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Gui-You Liu
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Run-Ling Wang
School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, P.R. China
Wei-Ren Xu
Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, P.R. China

Corresponding Author(s) : Run-Ling Wang

wangrunling@tijmu.edu.cn

Asian Journal of Chemistry, Vol. 23 No. 9 (2011): Vol 23 Issue 9

Abstract

A series of novel imidazolidine-2,4-dione derivatives were synthesized and their chemical structures were confirmed by 1H NMR and ESI-MS. The preliminary antidiabetic screening results demonstrated that the compound 3b showed some antidiabetic activity and could acted as lead compound for further design and discovery of antidiabetic agents.

Keywords

Synthesis Derivatives Imidazolidine-2,4-dione Antidiabetic agents
(1)
Cheng, X.-C.; Sun, S.-X.; Zhang, H.; Dong, W.-L.; Liu, G.-Y.; Wang, R.-L.; Xu, W.-R. Synthesis of Novel Imidazolidine-2,4-Dione Derivatives As Potential Antidiabetic Agents. ajc 2011, 23, 4114-4116.
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