Synthesis and Antimicrobial Activity of Novel Thiazolidinone and Azetidinone Derivatives
Corresponding Author(s) : S.S. Kshirsagar
sanpals24@rediffmail.com
Asian Journal of Chemistry,
Vol. 23 No. 9 (2011): Vol 23 Issue 9
Abstract
Reaction of 2,3-diketoquinoxaline in presence of phosphorus pentachloride and hydrazine hydrate gives 2-hydrazino-3-hydroxyquinoxalin (4) which on treatment with various aldehydes in appropriate solvent gives 2-p-anisyl-3-(3-hydroxy quinoxalin-2 yl-amino)-4-thiazolidinones (6) and 1-N-(3-hydroxy quinoxalin-2'yl-amino)-4-aryl-3-chloro-2-azetidinones (7). The structure of compounds 6a-6l and 7a-7l has been confirmed by IR and 1H NMR data. All these compounds were tested for their antimicrobial and antifungal activity against different microorganisms.
Keywords
Quinoxaline
NMDA receptor
Thiazolidinones
Azetidinones
Antimicrobial activity
Kshirsagar, S., Nimje, H., Chaudhari, P., Bayas, J., Patel, E., Karjikar, A., … Oswal, R. (2011). Synthesis and Antimicrobial Activity of Novel Thiazolidinone and Azetidinone Derivatives. Asian Journal of Chemistry, 23(9), 4021–4023. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10787
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX