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Vol. 28 No. 12 (2016): Vol 28 Issue 12

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Synthesis, Characterization and Antimicrobial Activity of L-Tryptophan Coordinated Copper(II) N,N-Donor Amino Acid Complexes

https://doi.org/10.14233/ajchem.2016.20069
V. Sheela Violet Rani
Department of Chemistry, GKM College of Engineering and Technology, Chennai-600 063, India
E. Prabakaran
Department of Chemistry, GKM College of Engineering and Technology, Chennai-600 063, India
D. Jesudurai
Department of Chemistry, GKM College of Engineering and Technology, Chennai-600 063, India

Corresponding Author(s) : D. Jesudurai

jesuresearch@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 12 (2016): Vol 28 Issue 12

Abstract

Three L-tryptophan coordinated mixed amino acid copper(II) complexes of the type [Cu(L-Trp)(AA)] (where AA = L-proline, L-isoleucine and L-methionine) are synthesized. Two N,N-donor base-coordinated L-tryptophan complexes of the type [Cu(L-Trp)(B)] (where B = ethylene diamine and o-phenylene diamine) are also prepared in good yield. The stoichiometric reaction between metal and ligand is in the ratio of 1:1. The resulting complexes are characterized by UV-visible, FT-IR, EPR spectroscopic techniques and also by mass spectrometry. Infrared spectra show that amino acids act as bidentate ligands in all the complexes. Infrared spectroscopy confirms the ligand coordination to the metal ions through carboxyl and amino groups. The electrochemical behaviour of the complexes 1-5 was investigated using in the presence of 0.1 M PBS as supporting electrolyte. The antibacterial activity of complexes 1-5 was tested against Gram-negative and Gram-positive micro-organisms. There is an enhanced antibacterial activity was observed with complex 2 compared to the other complexes 1, 3, 4 and 5.

Keywords

Copper(II) complexes L-Tryptophan Ethylene diamine o-Phenylene diamine Amino acids Antibactrial activity
Violet Rani, V. S., Prabakaran, E., & Jesudurai, D. (2016). Synthesis, Characterization and Antimicrobial Activity of L-Tryptophan Coordinated Copper(II) N,N-Donor Amino Acid Complexes. Asian Journal of Chemistry, 28(12), 2685–2694. https://doi.org/10.14233/ajchem.2016.20069
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